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Immortality, an ancient fantasy revived by transhumanism

Stéphane Charpier
Stéphane Charpier
Professor of Neuroscience at Sorbonne University and Research Director at Institut du cerveau de Paris
Cécilia Calheiros
Cécilia Calheiros
PhD in sociology, specialist in transhumanism
Key takeaways
  • Transhumanism is a school of thought that promotes the idea of surpassing the human condition.
  • With life expectancy rising steadily over the last few decades, advances in neuroscience are bringing the ideological aspects of this school of thought to light.
  • Over the centuries, the definition of death has evolved considerably, but today it is considered to be the absence of brain activity.
  • Researchers have identified distinctive signals associated with death and resuscitation, making the definition of death more complex from a neurophysiological point of view.
  • Now, some transhumanist movements are no longer aiming for immortality, but amortality, i.e. a considerably prolonged life in good health.
  • Immortality is a long-standing human goal, but what is new is the techno-scientific justification for this ambition.

From being “brain dead” to the “mind down­load” envi­sa­ged by trans­hu­ma­nists, the boun­da­ry bet­ween life and death conti­nues to be shrou­ded in mys­te­ry. But in the face of the hopes of immor­ta­li­ty that they raise, the limits of scien­ti­fic rea­li­ty and the human condi­tion must be faced. Recent advances in neu­ros­cience have led to a rejec­tion of this desire to “kill death”, which has more to do with ideo­lo­gy than with a serious tech­no-scien­ti­fic project.

Thanks to advances in science and medi­cine, huma­ni­ty has never cea­sed to delay its own demise. While a contem­po­ra­ry of Char­le­magne was born with a life expec­tan­cy of bare­ly 30 years, INED pre­dicts that a citi­zen of the Euro­pean Union born in 2022 will live an ave­rage of just over eight decades. But some people ima­gine going even fur­ther. Recent scien­ti­fic revo­lu­tions in arti­fi­cial intel­li­gence, gene­tics, bio­lo­gy and neu­ros­cience, com­bi­ned with the emer­gence of trans­hu­ma­nism (a move­ment that pro­motes the idea of trans­cen­ding the human condi­tion), have brought the quest for immor­ta­li­ty back to centre stage, or at least for a signi­fi­cant exten­sion of life.

But before we can unders­tand how and why we delay death, we need to be able to define it. And the ques­tion is not so simple : “As a scien­tist, I don’t know what death is”, admits Sté­phane Char­pier, pro­fes­sor of neu­ros­cience at Sor­bonne Uni­ver­si­ty and direc­tor of the Brain Neu­ros­cience team at Inserm. For him, it is a “pri­ma­ry concept” that only takes on mea­ning in oppo­si­tion (“in the nega­tive”) to life. This is why his work involves “stu­dying death by trying to unders­tand what is hap­penng in a brain that is still alive”.

A case of brain death des­cri­bed by P. Mol­la­ret and M. Gou­lon in 1959, in the Revue Neu­ro­lo­gique. The authors go on to point out that “the sur­vi­val of such a patient auto­ma­ti­cal­ly ceases as soon as res­pi­ra­to­ry or cir­cu­la­to­ry control is stopped”

The corpse with the beating heart

The idea that a human being with a bea­ting heart is neces­sa­ri­ly alive is still wide­ly held. Howe­ver, when Pierre Mol­la­ret and Mau­rice Gou­lon dis­co­ve­red brain death1 in the middle of the 20th cen­tu­ry, they dis­pro­ved this prin­ciple and “engen­de­red,” accor­ding to Sté­phane Char­pier, “a new sta­tus of human exis­tence”, by des­cri­bing the pos­si­bi­li­ty of having a corpse with a bea­ting heart, but whose brain has been des­troyed. The two resus­ci­ta­tors were in fact the first to concep­tua­lise the prin­ciple of brain death. They defi­ned this sta­tus as a “coma in which, in addi­tion to the total abo­li­tion of the func­tions of rela­tio­nal life (editor’s note : absence of mus­cu­lar and ner­vous reac­ti­vi­ty), there is not only dis­tur­bance, but also total abo­li­tion of vege­ta­tive life (editor’s note : absence of spon­ta­neous respiration)”.

In this way, the car­dio­cen­tric vision of exis­tence is no lon­ger rele­vant and, from a medi­cal point of view, what makes a human being not dead is no lon­ger his bea­ting heart, but his living brain.

Since 2012, the WHO has also adop­ted this brain-cen­tric view­point in its defi­ni­tion of death : “the per­ma­nent and irre­ver­sible disap­pea­rance of the capa­ci­ty for conscious­ness and of all func­tions of the brain stem”. A human being is the­re­fore consi­de­red to be alive as soon as his or her brain is capable of gene­ra­ting “elec­tri­cal back­ground noise”, as Sté­phane Char­pier points out. This phe­no­me­non, which results from the brain’s spon­ta­neous, endo­ge­nous acti­vi­ty, can be mea­su­red using an elec­troen­ce­pha­lo­gram or microe­lec­trodes that scien­tists insert inside neurons.

Immortality, the permanent horizon of transhumanism

Elec­tro-neu­ro­nal stu­dies enable resear­chers to “dif­fe­ren­tiate three phy­sio­lo­gi­cal dimen­sions of exis­tence : living, awake and conscious”, to which par­ti­cu­lar elec­tri­cal signa­tures cor­res­pond. As Sté­phane Char­pier, author of La science de la résur­rec­tion2, explains, this trip­tych makes it pos­sible to unders­tand that “what makes a human being not dead is no lon­ger just his bea­ting heart, or his abi­li­ty to breathe spon­ta­neous­ly, but his capa­ci­ty to pro­duce a conscious sub­jec­tive experience.”

So, if death coin­cides with the inabi­li­ty to be conscious, does the quest for immor­ta­li­ty che­ri­shed by trans­hu­ma­nists amount to kee­ping our brains alive after our bodies have fai­led us ? “Not exclu­si­ve­ly,” replies Ceci­lia Cal­hei­ros, a socio­lo­gist spe­cia­li­sing in health and reli­gion who devo­ted her doc­to­ral the­sis to the sub­ject. “Trans­hu­ma­nism aims for the end of the human as it exists and the advent of a new one,” she sums up, “which will be either immor­tal or amor­tal, depen­ding on whe­ther you’re a North Ame­ri­can or French trans­hu­ma­nist.” By amor­tal, we mean a human being whose lifes­pan in good health is consi­de­ra­bly exten­ded, without being eter­nal. In short, the trans­hu­ma­nist pro­ject amounts to pro­po­sing a socie­ty where “the human condi­tion frees itself from its bio­lo­gi­cal limits”.

The wave of death is not fatal

In 2011, bored by a scien­ti­fic pre­sen­ta­tion at a confe­rence, Sté­phane Char­pier chose to read an article publi­shed in the jour­nal Plos One3, the title of which men­tions a mys­te­rious “Wave of Death”. In it, the authors assess the brain acti­vi­ty that occurs at the moment of death, “by stu­dying what hap­pens in the brain of a rat before, during and after deca­pi­ta­tion”, he explains. And, as expec­ted, “they found that this acti­vi­ty died out very qui­ck­ly, but that after a while a gigan­tic wave appea­red on the elec­troen­ce­pha­lo­gram, which had flat­te­ned out!” This is what the Dutch resear­chers call the “wave of death”, sug­ges­ting that it is the last signal a brain pro­duces before it final­ly shuts down.

Nothing less was nee­ded to arouse the neuroscientist’s curio­si­ty, and to get his Inserm team at the Ins­ti­tut du Cer­veau (Pitié Sal­pe­trière Hos­pi­tal in Paris) invol­ved in a pro­ject to stu­dy this phe­no­me­non in grea­ter detail. “We aban­do­ned the prin­ciple of deca­pi­ta­tion and set up a pro­to­col enabling us to switch off the brain, then rea­ni­mate it after­wards, while stu­dying brain acti­vi­ty using microe­lec­trodes inser­ted into the neu­rons of our test sub­ject,” sums up the researcher.

Elec­tro-cor­ti­co­gra­phic (EcoG) mea­su­re­ments in rats, after indu­ced Anoxia onset and a resus­ci­ta­tion attempt. In figure A, the upper tra­cings show suc­cess­ful resus­ci­ta­tion and the onset of the resus­ci­ta­tion wave (WoR). (Modi­fied from Schramm et al., 2020). Source : Char­pier S (2023)4.

After confir­ming the neu­ro­nal phe­no­me­non of the wave of death, when the test sub­jects were rea­ni­ma­ted, the resear­chers wit­nes­sed the appea­rance of “a second wave ! […] An elec­tri­cal sign of the brain’s return to life”, which they named the “rea­ni­ma­tion wave”. The scien­tists have thus cha­rac­te­ri­sed two neu­ro­nal mar­kers that help deci­pher the boun­da­ry bet­ween life and death. Para­me­ters are still lacking to define death pre­ci­se­ly from a neu­ro­phy­sio­lo­gi­cal point of view, but their work makes it pos­sible to attri­bute a signa­ture to two dis­tinct states : “I may be dying” and “I may be coming back”.

A flat elec­troen­ce­pha­lo­gram doesn’t neces­sa­ri­ly mean that eve­ry­thing is over, which is why Sté­phane Char­pier says that “death is an asymp­tote”. A curve whose point of conver­gence with the end line is a more than inde­ci­sive horizon.

An illusion of eternity

Accor­ding to those who claim to be part of this move­ment, immor­ta­li­ty is only a “speck on the hori­zon” for the time being. To achieve it, some trans­hu­ma­nists advo­cate a bio­lo­gi­cal approach to coun­ter-aging (or “‘lon­ge­vi­ty”), with the aim of hal­ting or even rever­sing the aging pro­cess. Others believe that “true free­dom consists in deta­ching one­self from one’s phy­si­cal body”, says the resear­cher. In this case, the essence of exis­tence lies in the brain, whose memo­ries and func­tio­ning should be pre­ser­ved “to make it impe­ri­shable” by cryo­ge­nics, as pro­po­sed by the Alcor Life Exten­sion Foun­da­tion in the USA, or by mind uploa­ding pro­cesses. While these methods fail to approach the realm of the pos­sible, they do have the advan­tage of fue­ling the ima­gi­na­tions of many artists and science-fic­tion writers.

Boris Kar­loff in the role of the mons­ter (publi­ci­ty pho­to for the film Bride of Fran­ken­stein, 1935).

Illu­so­ry, then ? “Without a doubt,” says Sté­phane Char­pier. In his view, “the trans­hu­ma­nist pro­ject is a meta­phy­si­cal fable. We can increase our life expec­tan­cy, cor­rect defects and com­pen­sate for cer­tain weak­nesses, but increa­sing the human being as an enti­ty, or cryo­ge­ni­cal­ly sto­ring their brain, is quite sim­ply a pipe dream.” The neu­ros­cien­tist ack­now­ledges that humans are capable of pro­du­cing arti­fi­cial neu­ral net­works, of “tin­ke­ring with brains”, but consi­ders it uni­ma­gi­nable that a machine could pro­duce, or even repli­cate, the neu­ral pro­cesses under­lying subjectivity.

The means justify the end

Ulti­ma­te­ly, the inno­va­tive cha­rac­ter of trans­hu­ma­nism does not lie in the quest for eter­nal life. “What is new is the asser­tion that immor­ta­li­ty is plau­sible, thanks to a dis­course based on tech­no-scien­ti­fic advances. Trans­hu­ma­nist objec­tives are thus convin­cing players in key spheres of our socie­ties : indus­try, research, health, etc.”, points out Ceci­lia Cal­hei­ros. As a result, trans­hu­ma­nism is, in her view, “the most exa­cer­ba­ted expres­sion of neo­li­be­ral socie­ty, which urges eve­ryone to be the best ver­sion of them­selves and to constant­ly improve their skills.” The socio­lo­gist sees this move­ment “above all as an ideo­lo­gy, which rein­forces a power that is alrea­dy present.”

In the trans­hu­ma­nist context, the maxim that the end jus­ti­fies the means no lon­ger holds true, since this end (death) is des­ti­ned to disap­pear. The trans­hu­ma­nist myth is based on a reverse move­ment in which the means (tech­nos­ciences) jus­ti­fy a new end (immortality/amortality). The ambi­tion is “infi­nite mas­te­ry of the world” and of the bio­lo­gi­cal condi­tions of exis­tence, which brings trans­hu­ma­nists back to the myth of Fran­ken­stein, accor­ding to Sté­phane Char­pier. In his view, “with this novel, Mary Shel­ley wrote the first trans­hu­ma­nist text. She ima­gines a body made of frag­ments of corpses that lives and ful­fills the dream of trans­hu­ma­nists : to deprive human beings of death.”

The quest for immor­ta­li­ty and lon­ge­vi­ty has punc­tua­ted the his­to­ry of man­kind since its ear­liest begin­nings. It is embo­died in count­less myths about mor­tals who dared to aspire to the immor­ta­li­ty of the gods and were condem­ned to torment in return (Pro­me­theus, Ica­rus, etc.). The rise of trans­hu­ma­nism is a modern update of this ambi­tion. Unfi­ni­shed, this move­ment comes up against the wall of objec­ti­vi­ty and the scien­ti­fic approach. “Can we be conscious without a body ? Can a machine real­ly pro­duce sub­jec­ti­vi­ty?” asks Sté­phane Char­pier rhe­to­ri­cal­ly, by way of conclusion.

As long as trans­hu­ma­nists can’t pro­vide an objec­tive demons­tra­tion or proof that it’s pos­sible, death will remain the sha­red hori­zon for each and eve­ry one of us.

Samuel Belaud
1http://​site​.jero​me​coste​.free​.fr/​a​r​t​i​c​l​e​s​/​M​o​l​l​a​r​e​t​1​9​5​9.pdf
2https://​edi​tions​.flam​ma​rion​.com/​l​a​-​s​c​i​e​n​c​e​-​d​e​-​l​a​-​r​e​s​u​r​r​e​c​t​i​o​n​/​9​7​8​2​0​8​1​5​03335
3https://​www​.ncbi​.nlm​.nih​.gov/​p​m​c​/​a​r​t​i​c​l​e​s​/​P​M​C​3​0​2​9360/
4Bet­ween life and death : the brain twi­light zones. Front. Neu­ros­ci. 17:1156368

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